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双击自动滚屏 发布者:admin 发布时间:2009-2-13 8:49:08 阅读:692

银屑病(Psoriasis),中国中医又名“白疕”,民间有称“牛皮癣”,正式名称是银屑病

名称纠错

  使用牛皮癣一词来概括该病名称是十分不科学的,因为牛皮癣其实并不是癣,所谓癣医学上是指由于真菌感染引起的一些皮肤病,例如头癣、股癣、体癣、手足癣、指甲癣等。将这些癣局部的皮屑放在显微镜下常能发现真菌菌丝或真菌孢子,使用抗真菌药物进行治疗常能取得很好的疗效。而牛皮癣则不是由真菌感染引起的,医学上将其称为银屑病。它的发病原因很复杂,用抗真菌药物进行治疗往往无效。因此,不要望文生义,自己服用抗真菌药物或者乱用癣药外涂,以免浪费钱财,加重病情。由于银屑病皮损上覆盖有银白色的鳞屑,很有特征性,故西医称其为银屑病,是十分适宜的。处于对患者的尊重态度的,也应该提倡使用银屑病一词。

发病机理

  银屑病发病原因比较复杂,病因尚未明确。近年来多数学者认为,与遗传、感染、代谢障碍、免疫功能障碍、内分泌失调有关。现时已变得愈来愈普遍,特别是已发展的城市。银屑病并不是一种传染病,但因为银屑病患者的皮肤问题,往往给患者带来极大的身心痛苦和经济负担。

历史与现状

  古希腊人认为银屑病是众神的诅咒,并强迫银屑病患者摇铃,以防被传染。可知的名人中林彪、斯大林和曾国藩患有此种疾病。曾国藩患有严重的银屑病,每晚要婢女为他搔痒方能入睡,终身未能痊愈。过去由于以主妇及餐饮业工作者较多,曾一度认为是他们用来洗手的清洁剂有关。由于当时社会认为银屑病会传染,为免客人错误进食含有皮屑的食物而被传染,这些员工都会被餐厅解雇。现时普遍认为是因为生活压力过大,以致病者的内分泌失调,从而影响身体的免疫系统。所以,医生有时会为病者处方维生素B杂,以帮助纾缓压力;亦有医生认为病者应该多做带氧运动,使身体的自然调节机制透过运动而自我调整。在香港,有很多学生和教师都有局部的银屑病,主要集中在手掌、手臂、双腿或肩膀。在美国,最近有药厂发明了一种针剂,可以对严重患者的病程控制,使他们的皮肤回复光滑。这种针剂在2006年亦被引入到加拿大进行临床测试。不过,这种针剂不能根治银屑病,一旦停止注射,问题会立即重现。

  据调查,银屑病的发病率占世界人口的0.1%~3%,黄种人发病率为0.1%~0.3%,该病在人群中的发病率白种人明显高于黄种人,黑种人次之。截至1998年,我国银屑病患者已经达到280余万人。美国近年来的调查,其发病率为2.6%,患者多达600-700万人,远远高于中国。因该病顽固难治,仍被列为当今世界皮肤科领域的重要研究课题,是全世界皮肤科重点防治疾病之一。在近年来召开的全国银屑病防治协作会议上,与会专家一致认为“中医与中西医结合是防治银屑病的方向。西医抗癌药和激素类药物有严重的副作用,应尽量避免使用”。

  其皮损特征是红色丘疹或斑块上覆有多层银白色鳞屑,有明显的季节性,多数患者病情春季,冬季加重,夏季缓解。全国总患病率为0.72‰,男性多于女性,北方多于南方,城市高于农村。初发年龄男性为20-39岁,女性为15-39岁为最多。近十年来发病率有上升趋势。认为与工业污染和工作环境有关。

  银屑病病因尚未明了但初步观察与下列因素有关:

  ①遗传因素。多认为本病受多基因控制,同时也受外界其他因素的影响。

  ②感染因素。有人认为是病毒感染所致,虽发现过在表皮棘细胞核内有嗜酸性包涵体,但至今病毒培养未能成功。链球菌感染可能是本病的重要诱发因素,因急性点滴状银屑病发疹前常有急性扁桃体炎或上呼吸道感染。

  ③代谢障碍。有报告患者血清内脂质、胆固醇、球蛋白、糖、尿酸、钾等增高,叶酸含量降低,但皆未能作出肯定结论。也有人报告皮损内多胺及花生四烯酸增加。

  ④免疫功能紊乱。有的患者细胞免疫功能低下;有的血清IgG、IgA、IgE增高;部分患者血清中存在有抗 IgG抗体;有人用免疫荧光技术测到患者表皮角质层内有抗角质的自身抗体。

  ⑤精神因素。精神创伤和情绪紧张及过度劳累可诱发本病或使病情加重。

  ⑥其他。多数患者冬季复发、加重,夏季缓解或自然消退,但久病者季节规律性消失。也有的妇女患者经期前后加重,妊娠期皮疹消退,分娩后复发。氯喹、碳酸锂及β肾上腺能阻滞药等可使本病加重。

症状

  初起为针头或绿豆大小红色点疹,逐渐扩大,有的点疹互相隔合形成斑片。表面覆盖有干燥的银色鳞屑,轻轻刮除鳞屑,可见小片血点,这就是该病的特征。

  临床上多数患者皮疹表现为冬春季加重而夏秋季节自然减轻。因冬春季节气候寒冷、干燥,表皮血管收缩,皮肤供血差,肌肤失养所致。在个体免疫机能失调的情况下,可以导致该病的诱惑是缺乏抵抗力从而致病。

银屑病的临床表现

  根据银屑病的临床表现和病理特征,一般分为六种类型:

  1、寻常性银屑病:皮疹一般发生在头皮、躯干、四肢伸侧,是在皮肤上出现红色的丘疹,渐扩大融合成斑片或斑块,表面有较厚的银白色磷屑,形状不规则,有的有地图或岛屿样外观,有的皮损较小,较多,呈满天星外观,鳞屑层一层脱落,轻轻刮掉皮屑可看到薄薄的一层红膜,刮除红膜即可看到小小的出血点,有人称为血露,医学上又叫筛状出血,这就是寻常型牛皮癣临床特征。

  2、红皮病性银屑病:是较严重,较少见的一种,此型是指在约全身皮肤的70%以上呈弥漫性红色,暗红色浸润性皮损,表面有大量糠皮样皮屑,有时在腋下,大腿根部和脐部因肿胀而使表皮剥脱和渗出,口咽鼻及眼结膜可充血发红,患者常有发热畏寒,头疼及全身不适等症状。

  3、脓包性银屑病:分泛性及局限性。泛发性脓包型牛皮癣多为急性发病,可在数日至数周内脓疱泛发全身,先有密集的针尖大小潜在的小脓疱,很快融合成脓湖,常伴有高热、关节肿痛及全身不适,血常规化验可见白细胞增多,脓疮干涸后,随即脱屑,皮屑脱落后,又有新的脓疮出现。局限性脓疱型牛皮癣以掌趾脓疱型牛皮癣多见,在双手掌和足趾部有对称性红斑,红斑上出现针头大到栗大小到小脓疱:大约1-2周后自行干涸,脱屑后又有新的脓疱出现,反复绵延,病程顽固。

  4、关节病性银屑病:很少见,任何年龄均可发生,可同时发生于大小关节,但常见是手腕、手指及足趾小关节,脊柱关节也可发生。病变的关节有红肿、疼痛、严重的关节腔有积液,关节附近皮肤肿胀活动受限,久之关节僵直,严重时X线下可见关节被破坏的情况,血沉快,常伴发热等全身症状,但类风湿凝集因子为阴性,关节炎型牛皮癣、皮肤损害多伴有厚厚的像蛎壳状的皮损,也可仅有寻常型牛皮癣的红斑和银屑的皮肤损害。

  5、掌跎脓包病:包括掌跎脓包性银屑病和脓包性细菌疹。

  6、连续性肢端皮炎:以无菌性的脓疱为其特征,因此也有人认为与脓包性银屑病为同一种疾病。也有人认为是脓包性银屑病的一个亚型,但也有不同意见,认为应该是一个独立疾病。好发于中年人,多数由外伤后引起。

危害

  牛皮癣虽不直接影响生命,但是对身体健康和身心健康有直接影响。

  牛皮癣病的主因活性氧,是肌体代谢的有害产物,渗杂在血液细胞间质中,导致肌体内环境污染,血液纯质的改变。出现血热、血燥、血瘀,蕴积滞阻过 多导致瘟毒发于肌肤。长年反复发作,病程迁延日久耗血伤精,肌肤失养,枯燥瘙痒,伤神失眠,摧残身体。

  牛皮癣的诱因多为精神因素,由于过度劳累,家庭纠纷,亲人亡故,经济问题等使患者精神过度紧张,情绪抑郁,可引起一系列心理反应,导致内分泌紊乱,免疫功能下降,从而促进了银屑病的发生与发展。

  中医认为,情志内伤,气机壅滞,郁久化火,毒热伏于营血而发生银屑病,因此在遇有不可抗拒的天灾人祸时,患者应尽量控制情绪,尽量保持心情平静,保证充足睡眠,必要时可适量服用镇静剂。

注意事项

  牛皮癣患者除了要积极配合医生治疗以外在日常生活中要注意:

  1、3大忌口: 忌酒、忌海鲜、忌辛辣。关于忌口,也有不同说法, 也有人认为,忌口应该视个体差异而定,一味忌口,将使人体丧失大量营养,不利病情好转。

  2、溶血性链球菌感染是本病的一诱发因素,尽可能避免感冒、扁桃腺炎、咽炎的发生。一旦发生应积极对症治疗,以免加重牛皮癣。经常因扁桃腺化脓而诱发本病或加重本病的建议行扁桃腺摘除术。 对于此条扁桃体摘除,应该慎重。

  3、消除精神紧张因素,避免过于疲劳,注意休息。

  4、居住条件要干爽、通风、便于洗浴。

  5、在日常用药中,抗疟药、β-受体阻滞剂均可诱发或加重病情。

  6、内分泌变化、妊娠均可诱发本病并使其加重。

  7、多食富含维生素类食品,如新鲜水果、蔬菜等。

  8、清洗患处时,动作要轻揉,不要强行剥离皮屑,以免造成局部感染,如红、肿、热、痛,影响治疗,使病程延长。

  9、银屑病临床暂时痊愈后,其免疫功能、微循环、新陈代谢仍未完全恢复正常,一般需要2-3个月后才能复原。所以在临床痊愈后,即外表皮损完全消退后,应再继续服用2-3个疗程药物进行巩固,使病毒清理更彻底,以免复发。

日常的生活饮食保健及有益食物疗法

  按中医辩证分析,牛皮癣存在有"血燥、血热、血虚"之象,而从西医的角度讲,则是由于角质细胞过度增殖,各种生化代谢紊乱所致。

  因此,凡有"养血、凉血、活血"之效或具有抑制细胞DNA合成,改善微循环功能的食物,对牛皮癣均有好处,如水果饮料之类的乌梅、柚子等都具有清热、凉血、解渴生津的作用,不仅含丰富的维生素及微量元素,还可以降低血脂、血粘度,西柚和胡柚已被证实具有抑制细胞的有效分裂的作用,是夏天防治牛皮癣有效水果。

常识

  1.本病尚无特殊的预防方法和可以肯定的治疗方法;

  2.本病不传染,即使是重症患者;

  3.治疗同时须解除患者思想顾虑,避免可能的诱因,忌食刺激性食物,避免激发性疗法,禁搔抓及热水洗烫;

  4.对银屑病适当的治疗可获近期临床治愈,但多数患者可能复发;

  5.一般无内脏损害,预后良好;

  6.由于需要禁食某些食物,患者需调整增加其他食物,防止营养不良。

现今可知的治疗方式

  需要重点强调的是现在没有一种方法可以治愈银屑病,且各种治疗方法都带有较强的副作用。不少患者病情的恶化来自于药物刺激,而非疾病本身。任何广告中自称能够治愈银屑病都是极端不负责的行为,很多会对患者的病体和心理造成严重伤害,现今所谓的治愈仅仅是暂时的临床治愈,但扔会复发,根据个体差异的不同,复发周期长短不同。

 
 

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